What is already known about this topic?
Data on epidemiologic and clinical characteristics of monkeypox in persons aged ≤12 years (children) and adolescents during the ongoing 2022 monkeypox outbreak are limited.
What is added by this report?
During May 17–September 24, 2022, Monkeypox virus (MPXV) infections in children and adolescents aged <18 years were rare, representing 0.3% of all U.S. cases; none resulted in critical illness or death. Younger children typically acquired MPXV infection after skin-to-skin contact with a household member with monkeypox during caregiving activities; adolescents were most frequently exposed through male-to-male sexual contact.
What are the implications for public health practice?
Additional monkeypox cases in children and adolescents might be prevented through strengthened vaccination efforts and education around preventive measures and sexual health.